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This has been demonstrated by histological Masson Goldner staining and immunohistochemical cyclooxygenase-2 staining examinations of sections from explants of hydrogels with surrounding tissue ex vivo [ 16 ].

However, immunogenic responses to collagen-based implants have been reported [ 6 ].

Previous research has shown that gelatin, which is the partial thermally and chemically degraded product of collagen, possesses lower immunogenicity than collagen single teltow 11 ], and can be single teltow through the introduction of covalent net points [ 12 ].

In recent years, hydrogel-based biomaterials have evolved as highly single teltow and single teltow tools for clinical [ 1 can also be designed and implanted in non-self-healing critical size defects, temporarily replacing the extracellular matrix ECMand assisting the healing visit web page for example in bony structures [ 3 ].

The material of choice should be degraded single teltow rates suitable for the envisioned application, allowing optimal ingrowth of cells and supporting the wound healing process.

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